Endocrine Abstracts

Insulin-like peptide 3 (INSL3) is a peptide hormone secreted exclusively in boys and men by the mature Leydig cells of the testes. It acts through a unique G-protein-coupled receptor, called RXFP2. In the female INSL3 regulates ovarian antral follicle growth. Whereas INSL3 in the male foetus is responsible for the first phase of testicular descent, in the adult it appears to support spermatogenesis and bone health. Importantly, it is...

Background: Hypogonadotrophic hypogonadism is characterised by hypogonadism in the context of low/inappropriately normal gonadotrophin levels. Congenital Hypogonadotrophic Hypogonadism (CHH) occurs due to disrupted GnRH neuronal migration, or impaired hypothalamic GnRH secretion or action. However, no direct test of hypothalamic GnRH neuronal function currently exists. Kisspeptin-54 is a neuropeptide that stimulates endogenous hypothalamic GnRH release. Thus, we investigated w...